Authors: Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill L
Title: The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial
Source: Journal of Autism and Developmental Disorders 2006 36(3): 413-420
Year: 2006
Research Design: Randomised Controlled Trial
Rating Score: 05/10
This rating is confirmed
Eligibility specified - Y
Random allocation - Y
Concealed allocation - N
Baseline comparability - N
Blind subjects - Y
Blind therapists - N
Blind assessors - Y
Adequate follow-up - N
Intention-to-treat analysis - N
Between-group comparisons - Y
Point estimates and variability - Y
Abstract:

This study tested the efficacy of a gluten-free and casein-free (GFCF) diet in treating autism using a randomized, double blind repeated measures crossover design. The sample included 15 children aged 2-16 years with autism spectrum disorder. Data on autistic symptoms and urinary peptide levels were collected in the subjects' homes over the 12 weeks that they were on the diet. Group data indicated no statistically significant findings even though several parents reported improvement in their children. Although preliminary, this study demonstrates how a controlled clinical trial of the GFCF diet can be conducted, and suggests directions for future research. ©Springer
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