Authors: |
Jahromi LB, Kasari CL, McCracken JT, Lee LSY, Aman MG, McDougle CJ, Scahill L, Tierney E, Arnold LE, Vitiello B, Ritz L, Witwer A, Kustan E, Ghuman J, Posey DJ |
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Title: |
Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity |
Source: |
Journal of Autism and Developmental Disorders 2009 39(3): 395-404 |
Year: |
2009 |
Research Design: |
Randomised Controlled Trial |
Rating Score: |
06/10 This rating is confirmed Eligibility specified - N Random allocation - Y Concealed allocation - N Baseline comparability - Y Blind subjects - Y Blind therapists - N Blind assessors - Y Adequate follow-up - N Intention-to-treat analysis - N Between-group comparisons - Y Point estimates and variability - Y |
Abstract: |
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity. ©Springer |
Access: |
Paywall |