Authors: Yang J, Tamares S, Crawley BK
Title: Laryngeal Solitary Fibrous Tumor: A Case Report and Systematic Review
Source: Journal Of Voice 2021 35(1): 136-142
Year: 2021
Research Design: Systematic Review

Objectives/Hypothesis: Solitary fibrous tumors are spindle cell neoplasms of mesenchymal origin that rarely occur in the larynx and may be mistaken for other pathologies. This case presentation and systematic review investigates presentation, treatment modalities, and outcomes of this unusual tumor. Study Design: Systematic review of PubMed, CINAHL, Web of Science, and EMBASE including a novel case presentation Methods: A systematic search according to the PRISMA guidelines was performed to isolate the reports of solitary fibrous tumors arising in the larynx and its subsites. Variables analyzed included patient demographics, presenting symptoms, smoking status, concurrent tumors, imaging studies, biopsy results, treatment, outcomes, and follow-up. Our additional report provides the second such description of this lesion originating within the true vocal fold. Result(s): Systematic review revealed 21 previous reports of solitary fibrous tumors originating from laryngeal subsites. The most common presenting symptom was dysphonia. All patients underwent local excision. Two patients had recurrences. Our patient presented with progressive dysphonia over 4 years. Stroboscopic examination revealed a large translucent mass of the left vocal fold. Local excision of the tumor was achieved with transoral resection with KTP laser. Immunohistochemical staining demonstrated a strong positivity for CD34 and HMW CK34BE12. Nine-month follow-up has not revealed any evidence of persistent or recurrent disease. Conclusion(s): Laryngeal solitary fibrous tumors are rare and are unlikely to recur in the absence of malignant findings. Complete surgical resection is an acceptable treatment for this lesion accompanied by appropriate follow-up.

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